//// Integration of Wilson model with multistep ODE solver clear; clf; function ydot=wilson_ode(t,y) // ode for wilson equations //// parameters of the model: 1=K,R; 2=Ca,T; 3=KCa,H; 4=Na; g(1)=26; g(2)=2.25; g(3)=9.5; g(4)=1; E(1)=-.95; E(2)=1.20; E(3)=E(1); E(4)=.50; tau(1)=1/4.2; tau(2)=1/14; tau(3)=1/45; V=y(4); y3=y(1:3); x0(1)=1.24 + 3.7*V + 3.2*V^2; x0(2)=4.205 + 11.6*V + 8 *V^2; x0(3)=3*y(2); ydot=tau.*(x0-y3); y3(4)=17.8 + 47.6*V +33.8*V^2; I=g.*y3.*(y(4)-E); ydot(4)=I_ext-sum(I); endfunction //// Integration: //1: Equilibration: no external input; y0=zeros(4,1); y0(4)=-1; I_ext=0; t=(0:100)'; y=ode(y0,t(1),t,wilson_ode); //2: Integration with external input; y0=y(:,size(t,1)); I_ext=1; t=(0:200)'; y=ode(y0,t(1),t,wilson_ode); //// Ploting Results plot(t,100*y(4,:)); xlabel('Time'); ylabel('Membrane potential');